Human tuberculosis--an ancient disease, as elucidated by ancient microbial biomolecules.
نویسنده
چکیده
Tuberculosis is a major cause of death but infected people with effective immunity may remain healthy for years, suggesting long-term co-existence of host and pathogen. Direct detection and characterisation of ancient microbial DNA and lipid biomarkers confirms palaeopathological diagnoses. Archaeological Mycobacterium tuberculosis resembles extant lineages indicating the timescale for evolutionary changes is considerably longer than originally believed.
منابع مشابه
Molecular analysis of ancient microbial infections.
The detection of ancient microbial DNA offers a new approach for the study of infectious diseases, their occurrence, frequency and host-pathogen interaction in historic times and populations. Moreover, data obtained from skeletal and mummified tissue may represent an important completion of contemporary phylogenetic analyses of pathogens. In the last few years, a variety of bacterial, protozoal...
متن کاملA new era in palaeomicrobiology: prospects for ancient dental calculus as a long-term record of the human oral microbiome
The field of palaeomicrobiology is dramatically expanding thanks to recent advances in high-throughput biomolecular sequencing, which allows unprecedented access to the evolutionary history and ecology of human-associated and environmental microbes. Recently, human dental calculus has been shown to be an abundant, nearly ubiquitous, and long-term reservoir of the ancient oral microbiome, preser...
متن کاملInsights gained from ancient biomolecules into past and present tuberculosis-a personal perspective.
Ancient and historical tuberculosis (TB) can be recognized by its typical paleopathology in human remains. Using paleomicrobiology, it is possible to detect many more individuals infected with TB but with no visible lesions. Due to advances in molecular analysis over the past two decades, it is clear that TB was widespread in humans from the Neolithic period and has remained so until the presen...
متن کاملInsights from paleomicrobiology into the indigenous peoples of pre-colonial America - A Review
This review investigates ancient infectious diseases in the Americas dated to the pre-colonial period and considers what these findings can tell us about the history of the indigenous peoples of the Americas. It gives an overview, but focuses on four microbial pathogens from this period: Helicobacter pylori, Mycobacterium tuberculosis, Trypanosoma cruzi and Coccidioides immitis, which cause sto...
متن کاملTuberculosis & traditional medicine: fighting the oldest infectious disease, using the oldest source of medicine
It is believed that tuberculosis has been killing human beings for over 4000 years. Several reports exist of ancient Egyptian mummies having signs of tubercular decay in their bodies. After the discovery of powerful anti-TB drugs such as streptomycin, isoniazid and rifampin during 1940-70s, it was thought that TB would be gone from the face of the earth, but tuberculosis still remains one of th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Microbes and infection
دوره 11 14-15 شماره
صفحات -
تاریخ انتشار 2009